Articles in Press
Mauricio F. Silvaa, Morris Shermanb
Received 11 April 2011; received in revised form 17 May 2011; accepted 18 May 2011. published online 28 June 2011.
Accepted Manuscript
Abstract
Liver transplantation is a well-established treatment in a subset of patients with cirrhosis and hepatocellular carcinoma. The Milan criteria (single nodule up to 5cm, up to 3 nodules none larger than 3cm, with no evidence of extrahepatic spread or macrovascular invasion) have been traditionally accepted as standard of care. However, some groups have proposed that these criteria are too restrictive, and exclude some patients from transplantation who might benefit from this procedure. Transplanting patients with tumors beyond the established criteria falls into two categories, those whose tumors are beyond the Milan criteria at presentation without the use of treatment prior to transplantation (expanded criteria), and those in whom treatment allows the MC to be fulfilled (down-staging). Currently, however, there is no international consensus regarding these approaches in clinical practice. The purpose of this systematic review is to clarify this debate through a critical analysis of available data. Finally, some comments on predictive factors apart from morphological characteristics are also addressed.
Keywords: Hepatocellular carcinoma, Liver transplantation, Expanded criteria, Down-staging, Milan criteria, Systematic review, Evidence based medicine
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a Department of HBP Surgery and Transplantation, Santa Casa General Hospital, Porto Alegre, Brazil
b University of Toronto, University Health Network Toronto, ON, Canada
PII: S0168-8278(11)00495-8
doi:10.1016/j.jhep.2011.05.012
© 2011 Published by Elsevier Inc.
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